Neighbours logo used in 2021.
2021 was Neighbours 37th year in production.
The season premiere was Episode 8528 - 4 January 2021 and the finale was Episode 8751 - 9 December 2021.
Main characters[]
| Ranking | Character | Played by | Duration | Number of Episodes | Running total | Previous year's ranking |
|---|---|---|---|---|---|---|
| 1 | Terese Willis | Rebekah Elmaloglou | Full year | 150 | 1175 | 1 |
| 2 | David Tanaka | Takaya Honda | Full year | 148 | 673 | 8 |
| 3 | Toadfish Rebecchi | Ryan Moloney | Full year | 146 | 3272 | 3 |
| 4 | Kyle Canning | Chris Milligan | Full year | 137 | 1071 | 2 |
| 5 | Chloe Brennan | April Rose Pengilly | Full year | 129 | 503 | 4 |
| 6 | Paul Robinson | Stefan Dennis | Full year | 120 | 3160 | 6 |
| 7 | Roxy Willis | Zima Anderson | Full year | 112 | 306 | 13 |
| 8 | Aaron Brennan | Matt Wilson | Full year | 111 | 783 | 9 |
| = | Harlow Robinson | Jemma Donovan | Full year | 111 | 298 | 11 |
| = | Hendrix Greyson | Benny Turland | Full year | 111 | 264 | 10 |
| 9 | Ned Willis | Ben Hall | Full year | 109 | 492 | 13 |
| = | Nicolette Stone | Charlotte Chimes | Full year | 109 | 173 | 21 |
| 10 | Levi Canning | Richie Morris | Full year | 108 | 183 | 20 |
| 11 | Karl Kennedy | Alan Fletcher | Full year | 103 | 3407 | 15 |
| 12 | Mackenzie Hargreaves | Georgie Stone | Full year | 100 | 195 | 19 |
| 13 | Susan Kennedy | Jackie Woodburne | Full year | 99 | 3447 | 14 |
| 14 | Sheila Canning | Colette Mann | Full year | 99 | 1088 | 9 |
| 15 | Jane Harris | Annie Jones | Full year | 98 | 634 | 18 |
| 16 | Amy Greenwood | Jacinta Stapleton | Full year except March & April | 85 | 354 | 30 |
| 17 | Melanie Pearson | Lucinda Cowden | Full year except March | 58 | 289 | - |
| 18 | Yashvi Rebecchi | Olivia Junkeer | Until July | 55 | 396 | 16 |
| 19 | Bea Nilsson | Bonnie Anderson | Until May | 49 | 386 | 12 |
| 20 | Leo Tanaka | Tim Kano | From June except October | 42 | 420 | 36 |
| 21 | Dipi Rebecchi | Sharon Johal | Until March and June to July | 35 | 501 | 5 |
| 22 | Shane Rebecchi | Nicholas Coghlan | Until March | 32 | 508 | 7 |
| = | Nell Rebecchi | Scarlett Anderson | Full year except January | 32 | 410 | 26 |
| 23 | Clive Gibbons | Geoff Paine | Full year except December | 28 | 317 | 23 |
| 24 | Hugo Somers | John Turner | Full year except January | 24 | 118 | 27 |
| 25 | Glen Donnelly | Richard Huggett | From November | 13 | 124 | - |
| 26 | Pierce Greyson | Don Hany | June | 8 | 244 | 4 |
| 27 | Des Clarke | Paul Keane | January | 4 | 747 | 32 |
| = | Finn Kelly | Rob Mills | March | 4 | 242 | 22 |
| 28 | Lucy Robinson | Melissa Bell | November | 3 | 587 | 29 |
| 29 | Lucas Fitzgerald | Scott Major | April | 1 | 712 | - |
Guest Characters
- Britney Barnes - Montana Cox
- Olivia Bell - Alyce Platt
- Holden Brice - Toby Derrick
- Sheila Canning (II) - Shareena Clanton
- Brent Colefax - Texas Watterston
- Tim Collins - Ben Anderson
- Louis Curtain - Declan Dennis
- Emmett Donaldson - Ezra Justin
- Evelyn Farlow - Paula Arundell
- Councillor Jacinta Hay - Maurial Spearim
- Felicity Higgins - Isabella Giovinazzo
- Kane Jones - Barry Conrad
- Natasha Leighton - Samantha Healy
- Curtis Perkins - Nathan Borg
- Jesse Porter - Cameron Robbie
- Julie Quill - Gail Easdale
- Shay Quill - Yasmin Kassim
- Jay Rebecchi - Dhruv Malge
- Tally Rennick - Karrin Kose
- Constable Andrew Rodwell - Lloyd Will
- Abigail Tanaka - Mary Finn & Axelle Austin
- Isla Tanaka-Brennan - Axelle Austin & Mary Finn
- Maya Velasco - Christina O'Neill
- Rose Walker - Lucy Durack